By its nature, the cache optimization of a computational fluid dynamics (CFD) code is most readily assessed on relatively simple geometries and on problems that only require the core routines. Having previously conducted cache optimization on two in-house codes at the University of Kentucky, the structured two-dimensional code GHOST and the unstructured two-/three-dimensional code UNCLE, we are now examining how well these baseline improvements extend to more complicated geometries and flow conditions. This paper will present assessments of the performance of the optimized codes on established aerospace flows including turbulence flows, unsteady flows, and more complicated geometries. Additional code modifications to improve code performance in these flows will be presented, and the overall ability to translate code performance from core routines and simple geometries to widespread practical applications will be discussed.